Biognosy nthuav qhia cov kev tsim kho thev naus laus zis thiab kev tshawb fawb txog kev nce qib los ua kom cov proteome siv tau rau kev tshawb fawb txog lub neej ntawm 2023 HUPO World Congress

Kev txheeb xyuas cov ntaub ntawv tsis muaj cov tsev qiv ntawv thiab siv los ntawm kev kawm tshuab nrog Spectronaut ^® 18 muab kev lag luam-ua cov protein ntau ntau thiab dhau los rau DIA proteomics

Kev tshawb nrhiav kev sib koom tes tshiab siv TrueDiscovery CRO cov kev pabcuam platforms ^® thiab TrueTarget ^® Ua kom pom qhov ntau qhov tseeb thiab dav siv tau ntawm huab hwm coj spectrometry proteomics rau biomarker nrhiav pom thiab kev txhim kho tshuaj

Cov Khoom Siv Biognosys iRT yog lub hauv paus ntawm Bruker qhov kev soj ntsuam kev ua tau zoo hauv lub sijhawm tshiab hauv ProteoScape ™ tsom xam rau timsTOF cov cuab yeej

Biognosys, ib tug thawj coj inventor thiab tsim tawm ntawm huab hwm coj spectrometry (MS)-raws li proteomics daws, hnub no tshaj tawm nws kev koom tes nyob rau hauv lub Human Proteome Organization (HUPO) Ntiaj teb Congress Lub Cuaj Hli 17 txog 21 hauv Busan, Kaus Lim Qab Teb.

Kev koom tes hauv lub rooj sib tham

Thaum lub sij hawm kev sib tham Technology Advancements rau hnub Tuesday, Cuaj hlis 19, Dr. Lukas Reiter, Chief Technology Officer ntawm Biognosys, yuav muab ib tug "Bottom-up Proteomics siv DIA" nthuav qhia txog cov evolution, tsis ntev los no kev loj hlob, thiab yav tom ntej ntawm cov ntaub ntawv-yooj yim acquisition (DIA ). hauv MS-based proteomics. Biognosys tseem yuav nthuav tawm kaum daim ntawv tshaj tawm qhia txog kev tsim kho thev naus laus zis thiab cov ntaub ntawv tshawb fawb tshiab nrog nws cov kev pabcuam proteomics, software thiab cov khoom siv tshawb fawb. Biognosys 'pab neeg ntawm cov kws paub txog kev tshawb fawb yuav nthuav tawm thiab nthuav tawm cov software ntawm lub rooj muag zaub no. 408.

Bruker, tus khub tswv yim ntawm Biognosys, yuav qhia cov tswv yim tshiab rau timsTOF platform thiab Bruker ProteoScape ™ software suite, tsim kev sib koom ua ke nrog Spectronaut software ^® thiab Biognosys 'iRT Cov Khoom Siv los muab cov neeg siv khoom muaj peev xwm ua tau zoo rau kev ntseeg siab, siab-throughput proteomics.

Nqe lus

"Kuv zoo siab los nthuav qhia cov kev nce qib tseem ceeb nrog Biognosys 'MS proteomics thev naus laus zis thiab cov kev daws teeb meem uas coj peb rov los ze dua los ua kom cov proteome siv tau tiag tiag rau kev tshawb fawb, kev tsim tshuaj thiab kev txiav txim siab kho mob," Dr. Lukas Reiter . "Peb tsis tu ncua kev txhim kho software thiab cov khoom siv pov thawj ua rau cov neeg siv ntawm MS cov cuab yeej ua haujlwm ua haujlwm hauv lub xeev-ntawm-the-art, seamless workflows rau tob, siab-throughput, internally reproducible proteomics tshawb fawb. Peb cov kev pabcuam CRO muab cov neeg siv khoom siv tshuaj biopharmaceutical thiab kuaj mob nrog qhov tsis tau muaj dua qhov tseeb thiab kev nkag siab txhawm rau txhawm rau tshawb pom biomarker thiab txhim kho tshuaj. "

Spectronaut ^® 18: Kev lag luam-ua qhov tob, tsim tau thiab ua haujlwm zoo rau DIA cov ntaub ntawv tshuaj xyuas

Spectronaut 18, qhov tseeb version ntawm Biognosys' flagship software, muaj kev txhim kho kev txheeb xyuas tus nqi thiab kev ua kom muaj nuj nqis zoo, nrog rau ntau yam tshiab uas ua rau DIA proteomics ua haujlwm tau zoo thiab ua kom muaj peev xwm. Ntawm HUPO, Biognosys yuav nthuav tawm peb daim ntawv tshaj tawm qhia txog cov kev siv zog ntawm Spectronaut 18 rau kev nthuav dav proteome kom muaj nuj nqis. Cov kev hloov tshiab tseem ceeb suav nrog kev siv directDIA + ™ kom nrawm dua, kev tshuaj xyuas tsis pub qiv ntawv thiab cov deep learning nrog DeepQuant los txhim kho qhov kom muaj nuj nqis ntawm cov protein ntau tsawg los ntawm lub neural network rau kev cuam tshuam kev kho ntawm precursor ntau.

TrueDiscovery ^® : proven raug rau Kev tshawb pom ntawm biomarkers hauv oncology thiab neuroscience

Biognosys yuav nthuav tawm peb daim ntawv tshaj tawm qhia txog kev tshawb nrhiav biomarker thiab kev tshawb fawb txog tshuaj kho mob nrog cov neeg koom tes suav nrog, suav nrog Genmab, Johns Hopkins University School of Medicine, Stanford University, thiab University of Zurich. Cov kev tshawb fawb tau siv Biognosys 'TrueDiscovery platform rau kev tsis sib haum xeeb proteomics thiab sib sau ua ke qhia txog qhov muaj tseeb, muaj zog, thiab dav siv tau ntawm MS proteomics rau kev tshawb fawb oncology thiab neuroscience. Daim ntawv tshaj tawm thib plaub ntsuas qhov kev siv thev naus laus zis thiab kev lom zem ntxiv ntawm TrueDiscovery thiab Olink affinity-based platform ^{® Tshawb los ntawm Olink Proteomics AB rau plasma proteomics.}

TrueTarget ^® : Txhim kho lub hom phiaj kom muaj txiaj ntsig zoo thiab khi qhov chaw ua haujlwm hauv kev tshawb nrhiav tshuaj

Biognosys 'TrueTarget platform leverages txwv cov proteolysis mass spectrometry (LiP-MS) los pab txhawb kev txheeb xyuas thiab siv tau cov hom phiaj tshuaj. Daim ntawv tshaj tawm thawj zaug, hauv kev koom tes nrog InterAx, qhia TrueTarget lub peev xwm tshwj xeeb hauv kev txiav txim siab lub hom phiaj ntawm G protein-coupled receptor (GPCR) antagonist, kos nws qhov chaw sib txuas thiab muab cov qauv kev pom zoo rau hauv lub tshuab ua haujlwm. Ib daim ntawv tshaj tawm thib ob, hauv kev koom tes nrog Samsara Therapeutics, qhia txog qhov kev xav ntawm lub hom phiaj nrog TrueTarget, ua raws li kev tsis ncaj ncees proteome profiling nrog TrueDiscovery, ua kom muaj kev txheeb xyuas tau zoo thiab siv tau ntawm lub hom phiaj cov protein thiab txhim kho kev nkag siab ntawm cov kab mob lom hauv kev kho tshiab.

Biognosys thiab Bruker: Smooth workflows rau dia-PASEF ^® thiab QC ntawm timsTOF

Txhawm rau kom ua tiav MS kev ua tau zoo, Bruker qhia TwinScape ™, tus ntxaib digital rau timsTOF platform, sib cuam tshuam nrog ProteoScape software los txhawb kev tswj hwm lub sijhawm zoo (QC) nrog Biognosys iRT cov khoom siv. Cov peptides hauv cov khoom siv iRT tau ua tib zoo ua kom zoo rau kev ruaj ntseg, rhiab heev thiab tuav lub sijhawm ntau thiab cov khoom siv iRT tam sim no tuaj yeem siv rau kev tswj xyuas qhov zoo hauv Bruker's ProteoScape proteomics software. Biognosys Business Development Manager – Cov khoom, Dr. Sira Echevarria, yuav nthuav qhia yuav ua li cas Spectronaut muab kev txhim kho lub tsev qiv ntawv-dawb proteomic tsom xam rau dia-PASEF siv directDIA+ thaum Bruker lub HUPO noj su seminar rau hnub Tuesday, Cuaj hlis 19.

BlogInnovazione.it