Hanyoyin haɗakarwa Hanyoyin al'ada na bioconjugation suna da wasu kurakurai, kamar gubar da ba a kai ba, rage kwanciyar hankali, da yuwuwar asarar ayyukan nazarin halittu. Don magance waɗannan iyakokin, dandalin BOC Sciences XDC bioconjugation dandali yana amfani da hanyoyi daban-daban na ƙayyadaddun hanyoyin haɗin yanar gizo, gami da haɗakar amino acid mara kyau, haɗawar cysteine in injiniya, haɓakar enzyme-taimaka, gyaran glycan, da haɓakar glycoconjugation.
Yin niyya Isar da Magunguna, dandali na XDC bioconjugation kuma yana ba da cikakkun dabarun niyya waɗanda ke ba da damar isar da ƙwayoyi musamman zuwa wurin da ake so. Ɗaukar haɗin gwiwar magungunan ƙwayoyin cuta, batun da aka saba nazari na XDCs, a matsayin misali, Kimiyyar BOC ta ɓullo da hanyoyin sinadarai ko enzymatic ko haɗe-haɗensu don daidaita takamaiman amino acid don samar da ADCs tare da ingantattun lodin magunguna da wuraren da aka riga aka shirya.defigama ya duba.
Don isar da ingantattun kwayoyin da aka yi niyya, ƙwararrun Kimiyya na BOC dole ne su yi la'akari da abubuwan da suka haɗa da inganci, ikon kutsawa cikin sel, yuwuwar amsawar rigakafi, girman kwayoyin halitta, sauƙi na haɗawa, da farashi. Bin waɗannan jagororin, dandalin XDC ɗin sa yanzu yana da ikon samar da ingantattun dillalai masu inganci, waɗanda suka ƙunshi ƙwayoyin rigakafi, gutsuttsuran antibody, peptides da oligonucleotides. Isar da RNAi Har ila yau abin lura shi ne cewa dandalin XDC yana ba da kyakkyawar hanya don daidaita isar da magungunan cikin salula da aka yi niyya ta hanyar gyaran sinadarai na siRNA don ƙirƙirar haɗin gwiwa.
Waɗannan haɗin gwiwar siRNA irin su GalNAc-siRNA conjugates da antibody-siRNA conjugates sun inganta halaye dangane da magunguna, ɗaukar wayar salula, takamaiman manufa, da aminci. Dokta Carrie Taylor, mai magana da yawun BOC Sciences, ta bayyana mahimmancin wannan dandalin na XDC bioconjugation. Ya ce: “Babban fasaharmu na da nufin magance kalubalen da masana kimiyya ke fuskanta a fannin sarrafa kwayoyin halitta. Ta hanyar rage yawan gubar da aka yi niyya da kuma inganta zaman lafiyar haɗin gwiwa, mun yi imanin dandalin nazarin halittu na XDC zai ba da gudummawa sosai ga haɓaka ingantattun magunguna da kayan aikin bincike." Tare da fitowar dandali na XDC bioconjugation, BOC Sciences ya sake tabbatar da kudurinsa na haɓaka kirkire-kirkire da ƙarfafa masu bincike a cikin ƙoƙarinsu na samun ci gaba a kimiyyar halittu. "Yanzu komai ya shirya don saduwa da buƙatun bioconjugation na masu bincike daban-daban," in ji mai magana da yawun masanan.
BOC Sciences ita ce mai ba da sabis na bincike (bio) sinadarai da sabis na bioconjugation na Amurka. Tawagar kwararrun ta ta himmatu wajen inganta ci gaban kimiyya ta hanyar sabbin fasahohi da kuma ba wa masu bincike damar buɗe sabbin damar yin amfani da haɓakar magunguna.
Linna Green
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